Cheap Flights from Frankfurt to Rio Negro (FRA to MDE)

Mon Aug 11th 2025 Air Europa · UX 1506 Depart at 7:10pm from Frankfurt (FRA) Fly for 2h 45m Arrive at 9:55pm in Madrid (MAD)

Tue Aug 12th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Thu Jul 17th 2025 Air Europa · UX 1506 Depart at 7:10pm from Frankfurt (FRA) Fly for 2h 45m Arrive at 9:55pm in Madrid (MAD)

Fri Jul 18th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Tue Jul 15th 2025 Air Europa · UX 1506 Depart at 7:10pm from Frankfurt (FRA) Fly for 2h 45m Arrive at 9:55pm in Madrid (MAD)

Wed Jul 16th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Wed Jul 23rd 2025 Air Europa · UX 1506 Depart at 7:10pm from Frankfurt (FRA) Fly for 2h 45m Arrive at 9:55pm in Madrid (MAD)

Thu Jul 24th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Tue Aug 5th 2025 Air Europa · UX 1506 Depart at 7:10pm from Frankfurt (FRA) Fly for 2h 45m Arrive at 9:55pm in Madrid (MAD)

Wed Aug 6th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Wed Aug 13th 2025 Air Europa · UX 1506 Depart at 7:10pm from Frankfurt (FRA) Fly for 2h 45m Arrive at 9:55pm in Madrid (MAD)

Thu Aug 14th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Wed Jun 25th 2025 Air Europa · UX 1506 Depart at 7:10pm from Frankfurt (FRA) Fly for 2h 45m Arrive at 9:55pm in Madrid (MAD)

Thu Jun 26th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Thu Jul 10th 2025 Air Europa · UX 1506 Depart at 7:10pm from Frankfurt (FRA) Fly for 2h 45m Arrive at 9:55pm in Madrid (MAD)

Fri Jul 11th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Fri Aug 8th 2025 Air Europa · UX 1506 Depart at 7:10pm from Frankfurt (FRA) Fly for 2h 45m Arrive at 9:55pm in Madrid (MAD)

Sat Aug 9th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Tue Jun 24th 2025 Air Europa · UX 1506 Depart at 7:10pm from Frankfurt (FRA) Fly for 2h 45m Arrive at 9:55pm in Madrid (MAD)

Wed Jun 25th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Wed Aug 6th 2025 Air Europa · UX 1506 Depart at 7:10pm from Frankfurt (FRA) Fly for 2h 45m Arrive at 9:55pm in Madrid (MAD)

Thu Aug 7th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Thu Aug 7th 2025 Air Europa · UX 1506 Depart at 7:10pm from Frankfurt (FRA) Fly for 2h 45m Arrive at 9:55pm in Madrid (MAD)

Fri Aug 8th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Sun Aug 10th 2025 Air Europa · UX 1506 Depart at 7:10pm from Frankfurt (FRA) Fly for 2h 45m Arrive at 9:55pm in Madrid (MAD)

Mon Aug 11th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Thu Aug 14th 2025 Air Europa · UX 1506 Depart at 7:10pm from Frankfurt (FRA) Fly for 2h 45m Arrive at 9:55pm in Madrid (MAD)

Fri Aug 15th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Sun Aug 17th 2025 Air Europa · UX 1502 Depart at 10:55am from Frankfurt (FRA) Fly for 2h 45m Arrive at 1:40pm in Madrid (MAD)

Sun Aug 17th 2025 Avianca · AV 17 Depart at 5:00pm from Madrid (MAD) Fly for 10h 35m Arrive at 8:35pm in Medellín (MDE)

Thu Jun 26th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Thu Jun 26th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Fri Jul 11th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Fri Jul 11th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Thu Jul 17th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Thu Jul 17th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Fri Jun 20th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Fri Jun 20th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Thu Aug 14th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Thu Aug 14th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Mon Jul 21st 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Mon Jul 21st 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Mon Aug 11th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Mon Aug 11th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Wed Jun 25th 2025 Air Europa · UX 1502 Depart at 10:55am from Frankfurt (FRA) Fly for 2h 45m Arrive at 1:40pm in Madrid (MAD)

Wed Jun 25th 2025 Avianca · AV 11 Depart at 5:30pm from Madrid (MAD) Fly for 10h 29m Arrive at 8:59pm in Bogotá (BOG)

Wed Jun 25th 2025 Avianca · AV 8449 Depart at 10:20pm from Bogotá (BOG) Fly for 0h 57m Arrive at 11:17pm in Medellín (MDE)

Thu Aug 14th 2025 Iberia Airlines · IB 1334 Depart at 7:45pm from Frankfurt (FRA) Fly for 2h 50m Arrive at 10:35pm in Madrid (MAD)

Fri Aug 15th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Wed Jul 23rd 2025 Iberia Airlines · IB 766 Depart at 7:45pm from Frankfurt (FRA) Fly for 2h 50m Arrive at 10:35pm in Madrid (MAD)

Thu Jul 24th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Sun Aug 17th 2025 Air Europa · UX 1506 Depart at 7:10pm from Frankfurt (FRA) Fly for 2h 45m Arrive at 9:55pm in Madrid (MAD)

Mon Aug 18th 2025 Avianca · AV 11 Depart at 5:30pm from Madrid (MAD) Fly for 10h 29m Arrive at 8:59pm in Bogotá (BOG)

Mon Aug 18th 2025 Avianca · AV 8449 Depart at 10:20pm from Bogotá (BOG) Fly for 0h 57m Arrive at 11:17pm in Medellín (MDE)

Wed Jun 25th 2025 Iberia Airlines · IB 1328 Depart at 12:10pm from Frankfurt (FRA) Fly for 2h 50m Arrive at 3:00pm in Madrid (MAD)

Wed Jun 25th 2025 Avianca · AV 11 Depart at 5:30pm from Madrid (MAD) Fly for 10h 29m Arrive at 8:59pm in Bogotá (BOG)

Wed Jun 25th 2025 Avianca · AV 8449 Depart at 10:20pm from Bogotá (BOG) Fly for 0h 57m Arrive at 11:17pm in Medellín (MDE)

Thu Jul 17th 2025 Condor · DE 1502 Depart at 5:20am from Frankfurt (FRA) Fly for 2h 10m Arrive at 7:30am in Palma, Majorca (PMI)

Thu Jul 17th 2025 Air Europa · UX 6048 Depart at 12:25pm from Palma, Majorca (PMI) Fly for 1h 25m Arrive at 1:50pm in Madrid (MAD)

Thu Jul 17th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Thu Jul 17th 2025 Condor · DE 1772 Depart at 4:45am from Frankfurt (FRA) Fly for 2h 5m Arrive at 6:50am in Palma, Majorca (PMI)

Thu Jul 17th 2025 Air Europa · UX 6048 Depart at 12:25pm from Palma, Majorca (PMI) Fly for 1h 25m Arrive at 1:50pm in Madrid (MAD)

Thu Jul 17th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Sun Aug 3rd 2025 Air Europa · UX 1506 Depart at 7:10pm from Frankfurt (FRA) Fly for 2h 45m Arrive at 9:55pm in Madrid (MAD)

Mon Aug 4th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Thu Jun 19th 2025 TAP Portugal · TP 575 Depart at 6:05am from Frankfurt (FRA) Fly for 3h 15m Arrive at 8:20am in Lisbon (LIS)

Thu Jun 19th 2025 TAP Portugal · TP 1012 Depart at 10:20am from Lisbon (LIS) Fly for 1h 20m Arrive at 12:40pm in Madrid (MAD)

Thu Jun 19th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Wed Aug 6th 2025 TAP Portugal · TP 575 Depart at 6:05am from Frankfurt (FRA) Fly for 3h 15m Arrive at 8:20am in Lisbon (LIS)

Wed Aug 6th 2025 TAP Portugal · TP 1012 Depart at 10:20am from Lisbon (LIS) Fly for 1h 20m Arrive at 12:40pm in Madrid (MAD)

Wed Aug 6th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Sat Aug 9th 2025 TAP Portugal · TP 575 Depart at 6:05am from Frankfurt (FRA) Fly for 3h 15m Arrive at 8:20am in Lisbon (LIS)

Sat Aug 9th 2025 TAP Portugal · TP 1012 Depart at 10:20am from Lisbon (LIS) Fly for 1h 20m Arrive at 12:40pm in Madrid (MAD)

Sat Aug 9th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Fri Jul 18th 2025 TAP Portugal · TP 575 Depart at 6:05am from Frankfurt (FRA) Fly for 3h 15m Arrive at 8:20am in Lisbon (LIS)

Fri Jul 18th 2025 TAP Portugal · TP 1012 Depart at 10:20am from Lisbon (LIS) Fly for 1h 20m Arrive at 12:40pm in Madrid (MAD)

Fri Jul 18th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Thu Aug 7th 2025 TAP Portugal · TP 575 Depart at 6:05am from Frankfurt (FRA) Fly for 3h 15m Arrive at 8:20am in Lisbon (LIS)

Thu Aug 7th 2025 TAP Portugal · TP 1012 Depart at 10:20am from Lisbon (LIS) Fly for 1h 20m Arrive at 12:40pm in Madrid (MAD)

Thu Aug 7th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Thu Jul 24th 2025 TAP Portugal · TP 575 Depart at 6:05am from Frankfurt (FRA) Fly for 3h 15m Arrive at 8:20am in Lisbon (LIS)

Thu Jul 24th 2025 TAP Portugal · TP 1012 Depart at 10:20am from Lisbon (LIS) Fly for 1h 20m Arrive at 12:40pm in Madrid (MAD)

Thu Jul 24th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Fri Aug 8th 2025 TAP Portugal · TP 575 Depart at 6:05am from Frankfurt (FRA) Fly for 3h 15m Arrive at 8:20am in Lisbon (LIS)

Fri Aug 8th 2025 TAP Portugal · TP 1012 Depart at 10:20am from Lisbon (LIS) Fly for 1h 20m Arrive at 12:40pm in Madrid (MAD)

Fri Aug 8th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Fri Aug 8th 2025 TAP Portugal · TP 573 Depart at 7:40pm from Frankfurt (FRA) Fly for 3h 15m Arrive at 9:55pm in Lisbon (LIS)

Sat Aug 9th 2025 TAP Portugal · TP 1010 Depart at 7:55am from Lisbon (LIS) Fly for 1h 20m Arrive at 10:15am in Madrid (MAD)

Sat Aug 9th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Tue Jun 24th 2025 TAP Portugal · TP 573 Depart at 7:40pm from Frankfurt (FRA) Fly for 3h 15m Arrive at 9:55pm in Lisbon (LIS)

Wed Jun 25th 2025 TAP Portugal · TP 1010 Depart at 7:55am from Lisbon (LIS) Fly for 1h 20m Arrive at 10:15am in Madrid (MAD)

Wed Jun 25th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Wed Jun 25th 2025 TAP Portugal · TP 575 Depart at 6:05am from Frankfurt (FRA) Fly for 3h 15m Arrive at 8:20am in Lisbon (LIS)

Wed Jun 25th 2025 TAP Portugal · TP 1012 Depart at 10:20am from Lisbon (LIS) Fly for 1h 20m Arrive at 12:40pm in Madrid (MAD)

Wed Jun 25th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Tue Jul 15th 2025 TAP Portugal · TP 573 Depart at 7:40pm from Frankfurt (FRA) Fly for 3h 15m Arrive at 9:55pm in Lisbon (LIS)

Wed Jul 16th 2025 TAP Portugal · TP 1012 Depart at 10:20am from Lisbon (LIS) Fly for 1h 20m Arrive at 12:40pm in Madrid (MAD)

Wed Jul 16th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Wed Jun 25th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Wed Jun 25th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Fri Jul 18th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Fri Jul 18th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Sun Aug 17th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Sun Aug 17th 2025 Avianca · AV 17 Depart at 5:00pm from Madrid (MAD) Fly for 10h 35m Arrive at 8:35pm in Medellín (MDE)

Sun Jun 22nd 2025 Condor · DE 2236 Depart at 9:50pm from Frankfurt (FRA) Fly for 11h 50m Arrive at 2:40am in Panama (PTY)

Mon Jun 23rd 2025 Copa Airlines · CM 855 Depart at 9:05am from Panama (PTY) Fly for 1h 24m Arrive at 10:29am in Medellín (MDE)

Sun Jun 22nd 2025 Condor · DE 2236 Depart at 9:50pm from Frankfurt (FRA) Fly for 11h 50m Arrive at 2:40am in Panama (PTY)

Mon Jun 23rd 2025 Copa Airlines · CM 397 Depart at 9:31am from Panama (PTY) Fly for 1h 24m Arrive at 10:55am in Medellín (MDE)

Wed Jun 25th 2025 Condor · DE 2236 Depart at 9:50pm from Frankfurt (FRA) Fly for 11h 50m Arrive at 2:40am in Panama (PTY)

Thu Jun 26th 2025 Copa Airlines · CM 150 Depart at 6:53am from Panama (PTY) Fly for 1h 24m Arrive at 8:17am in Medellín (MDE)

Sun Jun 29th 2025 Condor · DE 2236 Depart at 9:50pm from Frankfurt (FRA) Fly for 11h 50m Arrive at 2:40am in Panama (PTY)

Mon Jun 30th 2025 Copa Airlines · CM 150 Depart at 6:53am from Panama (PTY) Fly for 1h 24m Arrive at 8:17am in Medellín (MDE)

Sun Jun 29th 2025 Condor · DE 2236 Depart at 9:50pm from Frankfurt (FRA) Fly for 11h 50m Arrive at 2:40am in Panama (PTY)

Mon Jun 30th 2025 Copa Airlines · CM 855 Depart at 9:05am from Panama (PTY) Fly for 1h 24m Arrive at 10:29am in Medellín (MDE)

Wed Jun 25th 2025 Condor · DE 2236 Depart at 9:50pm from Frankfurt (FRA) Fly for 11h 50m Arrive at 2:40am in Panama (PTY)

Thu Jun 26th 2025 Copa Airlines · CM 397 Depart at 9:31am from Panama (PTY) Fly for 1h 24m Arrive at 10:55am in Medellín (MDE)

Wed Jul 2nd 2025 Condor · DE 2236 Depart at 9:50pm from Frankfurt (FRA) Fly for 11h 50m Arrive at 2:40am in Panama (PTY)

Thu Jul 3rd 2025 Copa Airlines · CM 502 Depart at 12:51pm from Panama (PTY) Fly for 1h 24m Arrive at 2:15pm in Medellín (MDE)

Thu Jul 24th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Thu Jul 24th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Fri Aug 8th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Fri Aug 8th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Thu Aug 7th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Thu Aug 7th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Wed Aug 6th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Wed Aug 6th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Wed Jul 16th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Wed Jul 16th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Mon Aug 4th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Mon Aug 4th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Mon Aug 11th 2025 Iberia Airlines · IB 766 Depart at 7:45pm from Frankfurt (FRA) Fly for 2h 50m Arrive at 10:35pm in Madrid (MAD)

Tue Aug 12th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Mon Aug 4th 2025 Condor · DE 1500 Depart at 4:45am from Frankfurt (FRA) Fly for 2h 25m Arrive at 7:10am in Ibiza (IBZ)

Mon Aug 4th 2025 Air Europa · UX 6020 Depart at 10:20am from Ibiza (IBZ) Fly for 1h 15m Arrive at 11:35am in Madrid (MAD)

Mon Aug 4th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Thu Jun 19th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Thu Jun 19th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Mon Aug 11th 2025 Air France · AF 1819 Depart at 7:55pm from Frankfurt (FRA) Fly for 1h 25m Arrive at 9:20pm in Paris (CDG)

Tue Aug 12th 2025 Air France · AF 1300 Depart at 9:15am from Paris (CDG) Fly for 2h 5m Arrive at 11:20am in Madrid (MAD)

Tue Aug 12th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Tue Jul 15th 2025 Air France · AF 1819 Depart at 7:55pm from Frankfurt (FRA) Fly for 1h 25m Arrive at 9:20pm in Paris (CDG)

Wed Jul 16th 2025 Air France · AF 1300 Depart at 9:15am from Paris (CDG) Fly for 2h 5m Arrive at 11:20am in Madrid (MAD)

Wed Jul 16th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Thu Aug 14th 2025 Air France · AF 1819 Depart at 7:55pm from Frankfurt (FRA) Fly for 1h 25m Arrive at 9:20pm in Paris (CDG)

Fri Aug 15th 2025 Air France · AF 1300 Depart at 9:15am from Paris (CDG) Fly for 2h 5m Arrive at 11:20am in Madrid (MAD)

Fri Aug 15th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Thu Jun 19th 2025 Condor · DE 2114 Depart at 11:10am from Frankfurt (FRA) Fly for 11h 25m Arrive at 3:35pm in Cancún (CUN)

Fri Jun 20th 2025 Copa Airlines · CM 104 Depart at 8:11am from Cancún (CUN) Fly for 2h 42m Arrive at 10:53am in Panama (PTY)

Fri Jun 20th 2025 Copa Airlines · CM 764 Depart at 1:30pm from Panama (PTY) Fly for 1h 25m Arrive at 2:55pm in Medellín (MDE)

Thu Jul 3rd 2025 Air Europa · UX 1506 Depart at 7:10pm from Frankfurt (FRA) Fly for 2h 45m Arrive at 9:55pm in Madrid (MAD)

Fri Jul 4th 2025 Air Europa · UX 55 Depart at 3:05pm from Madrid (MAD) Fly for 10h 35m Arrive at 6:40pm in Panama (PTY)

Fri Jul 4th 2025 Copa Airlines · CM 155 Depart at 9:27pm from Panama (PTY) Fly for 1h 24m Arrive at 10:51pm in Medellín (MDE)

Sat Jun 21st 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Sat Jun 21st 2025 Air Europa · UX 55 Depart at 3:05pm from Madrid (MAD) Fly for 10h 35m Arrive at 6:40pm in Panama (PTY)

Sat Jun 21st 2025 Copa Airlines · CM 155 Depart at 9:27pm from Panama (PTY) Fly for 1h 24m Arrive at 10:51pm in Medellín (MDE)

Thu Jul 3rd 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Thu Jul 3rd 2025 Air Europa · UX 55 Depart at 3:05pm from Madrid (MAD) Fly for 10h 35m Arrive at 6:40pm in Panama (PTY)

Thu Jul 3rd 2025 Copa Airlines · CM 155 Depart at 9:27pm from Panama (PTY) Fly for 1h 24m Arrive at 10:51pm in Medellín (MDE)

Sun Jun 22nd 2025 Condor · DE 2116 Depart at 2:05pm from Frankfurt (FRA) Fly for 11h 25m Arrive at 6:30pm in Cancún (CUN)

Mon Jun 23rd 2025 AeroMéxico · AM 543 Depart at 4:27pm from Cancún (CUN) Fly for 2h 33m Arrive at 6:00pm in Mexico City (MEX)

Mon Jun 23rd 2025 AeroMéxico · AM 798 Depart at 7:00pm from Mexico City (MEX) Fly for 4h 35m Arrive at 12:35am in Medellín (MDE)

Tue Jul 8th 2025 Condor · DE 2114 Depart at 2:05pm from Frankfurt (FRA) Fly for 11h 25m Arrive at 6:30pm in Cancún (CUN)

Wed Jul 9th 2025 AeroMéxico · AM 543 Depart at 4:30pm from Cancún (CUN) Fly for 2h 30m Arrive at 6:00pm in Mexico City (MEX)

Wed Jul 9th 2025 AeroMéxico · AM 798 Depart at 7:10pm from Mexico City (MEX) Fly for 4h 32m Arrive at 12:42am in Medellín (MDE)

Sat Jun 28th 2025 Condor · DE 2114 Depart at 1:30pm from Frankfurt (FRA) Fly for 11h 25m Arrive at 5:55pm in Cancún (CUN)

Sun Jun 29th 2025 AeroMéxico · AM 537 Depart at 3:39pm from Cancún (CUN) Fly for 2h 31m Arrive at 5:10pm in Mexico City (MEX)

Sun Jun 29th 2025 AeroMéxico · AM 798 Depart at 7:00pm from Mexico City (MEX) Fly for 4h 35m Arrive at 12:35am in Medellín (MDE)

Fri Jul 18th 2025 Condor · DE 4355 Depart at 6:50am from Frankfurt (FRA) Fly for 1h 10m Arrive at 8:00am in Milan (MXP)

Fri Jul 18th 2025 Air Europa · UX 1066 Depart at 11:05am from Milan (MXP) Fly for 2h 10m Arrive at 1:15pm in Madrid (MAD)

Fri Jul 18th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Thu Jul 17th 2025 Condor · DE 4355 Depart at 6:50am from Frankfurt (FRA) Fly for 1h 10m Arrive at 8:00am in Milan (MXP)

Thu Jul 17th 2025 Air Europa · UX 1066 Depart at 11:05am from Milan (MXP) Fly for 2h 10m Arrive at 1:15pm in Madrid (MAD)

Thu Jul 17th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Wed Jul 16th 2025 Condor · DE 4355 Depart at 6:50am from Frankfurt (FRA) Fly for 1h 10m Arrive at 8:00am in Milan (MXP)

Wed Jul 16th 2025 Air Europa · UX 1066 Depart at 11:05am from Milan (MXP) Fly for 2h 10m Arrive at 1:15pm in Madrid (MAD)

Wed Jul 16th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Fri Jun 20th 2025 Condor · DE 4355 Depart at 6:50am from Frankfurt (FRA) Fly for 1h 10m Arrive at 8:00am in Milan (MXP)

Fri Jun 20th 2025 Air Europa · UX 1066 Depart at 11:05am from Milan (MXP) Fly for 2h 10m Arrive at 1:15pm in Madrid (MAD)

Fri Jun 20th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Fri Aug 15th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Fri Aug 15th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Tue Aug 12th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Tue Aug 12th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Sat Aug 9th 2025 Iberia Airlines · IB 1332 Depart at 6:30am from Frankfurt (FRA) Fly for 2h 50m Arrive at 9:20am in Madrid (MAD)

Sat Aug 9th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Sun Aug 3rd 2025 Iberia Airlines · IB 1334 Depart at 7:45pm from Frankfurt (FRA) Fly for 2h 50m Arrive at 10:35pm in Madrid (MAD)

Mon Aug 4th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Fri Jun 20th 2025 Condor · DE 2228 Depart at 11:45am from Frankfurt (FRA) Fly for 10h 0m Arrive at 3:45pm in Punta Cana (PUJ)

Fri Jun 20th 2025 Copa Airlines · CM 351 Depart at 6:36pm from Punta Cana (PUJ) Fly for 2h 44m Arrive at 8:20pm in Panama (PTY)

Sat Jun 21st 2025 Copa Airlines · CM 150 Depart at 6:53am from Panama (PTY) Fly for 1h 24m Arrive at 8:17am in Medellín (MDE)

Fri Aug 8th 2025 Iberia Airlines · IB 766 Depart at 7:45pm from Frankfurt (FRA) Fly for 2h 50m Arrive at 10:35pm in Madrid (MAD)

Sat Aug 9th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Sun Aug 17th 2025 Iberia Airlines · IB 1328 Depart at 12:10pm from Frankfurt (FRA) Fly for 2h 50m Arrive at 3:00pm in Madrid (MAD)

Sun Aug 17th 2025 Avianca · AV 17 Depart at 5:00pm from Madrid (MAD) Fly for 10h 35m Arrive at 8:35pm in Medellín (MDE)

Mon Jul 28th 2025 TAP Portugal · TP 575 Depart at 6:05am from Frankfurt (FRA) Fly for 3h 15m Arrive at 8:20am in Lisbon (LIS)

Mon Jul 28th 2025 TAP Portugal · TP 171 Depart at 12:35pm from Lisbon (LIS) Fly for 8h 45m Arrive at 4:20pm in Caracas (CCS)

Mon Jul 28th 2025 Avior Airlines · 9V 1412 Depart at 6:45pm from Caracas (CCS) Fly for 1h 45m Arrive at 7:30pm in Medellín (MDE)

Thu Aug 14th 2025 Condor · DE 4355 Depart at 6:50am from Frankfurt (FRA) Fly for 1h 10m Arrive at 8:00am in Milan (MXP)

Thu Aug 14th 2025 Air Europa · UX 1066 Depart at 11:05am from Milan (MXP) Fly for 2h 10m Arrive at 1:15pm in Madrid (MAD)

Thu Aug 14th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Thu Jun 26th 2025 Condor · DE 4355 Depart at 6:50am from Frankfurt (FRA) Fly for 1h 10m Arrive at 8:00am in Milan (MXP)

Thu Jun 26th 2025 Air Europa · UX 1066 Depart at 11:05am from Milan (MXP) Fly for 2h 10m Arrive at 1:15pm in Madrid (MAD)

Thu Jun 26th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Tue Aug 12th 2025 TAP Portugal · TP 575 Depart at 6:05am from Frankfurt (FRA) Fly for 3h 15m Arrive at 8:20am in Lisbon (LIS)

Tue Aug 12th 2025 TAP Portugal · TP 1012 Depart at 10:20am from Lisbon (LIS) Fly for 1h 20m Arrive at 12:40pm in Madrid (MAD)

Tue Aug 12th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Wed Jun 25th 2025 Condor · DE 4355 Depart at 6:50am from Frankfurt (FRA) Fly for 1h 10m Arrive at 8:00am in Milan (MXP)

Wed Jun 25th 2025 Air Europa · UX 1066 Depart at 11:05am from Milan (MXP) Fly for 2h 10m Arrive at 1:15pm in Madrid (MAD)

Wed Jun 25th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Fri Aug 15th 2025 Condor · DE 4355 Depart at 6:50am from Frankfurt (FRA) Fly for 1h 10m Arrive at 8:00am in Milan (MXP)

Fri Aug 15th 2025 Air Europa · UX 1066 Depart at 11:05am from Milan (MXP) Fly for 2h 10m Arrive at 1:15pm in Madrid (MAD)

Fri Aug 15th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Thu Jun 19th 2025 Condor · DE 4355 Depart at 6:50am from Frankfurt (FRA) Fly for 1h 10m Arrive at 8:00am in Milan (MXP)

Thu Jun 19th 2025 Air Europa · UX 1066 Depart at 11:05am from Milan (MXP) Fly for 2h 10m Arrive at 1:15pm in Madrid (MAD)

Thu Jun 19th 2025 Air Europa · UX 199 Depart at 3:25pm from Madrid (MAD) Fly for 10h 10m Arrive at 6:35pm in Medellín (MDE)

Wed Jul 16th 2025 Condor · DE 2236 Depart at 9:50pm from Frankfurt (FRA) Fly for 11h 50m Arrive at 2:40am in Panama (PTY)

Thu Jul 17th 2025 Copa Airlines · CM 150 Depart at 6:53am from Panama (PTY) Fly for 1h 24m Arrive at 8:17am in Medellín (MDE)

Sun Jul 6th 2025 Condor · DE 2236 Depart at 9:50pm from Frankfurt (FRA) Fly for 11h 50m Arrive at 2:40am in Panama (PTY)

Mon Jul 7th 2025 Copa Airlines · CM 150 Depart at 6:53am from Panama (PTY) Fly for 1h 24m Arrive at 8:17am in Medellín (MDE)

Sun Jun 22nd 2025 KLM Royal Dutch Airlines · KL 1814 Depart at 6:00am from Frankfurt (FRA) Fly for 1h 5m Arrive at 7:05am in Amsterdam (AMS)

Sun Jun 22nd 2025 KLM Royal Dutch Airlines · KL 757 Depart at 12:55pm from Amsterdam (AMS) Fly for 10h 55m Arrive at 4:50pm in Panama (PTY)

Sun Jun 22nd 2025 KLM Royal Dutch Airlines · KL 8885 Depart at 6:33pm from Panama (PTY) Fly for 1h 24m Arrive at 7:57pm in Medellín (MDE)

Tue Jun 24th 2025 KLM Royal Dutch Airlines · KL 1814 Depart at 6:00am from Frankfurt (FRA) Fly for 1h 5m Arrive at 7:05am in Amsterdam (AMS)

Tue Jun 24th 2025 KLM Royal Dutch Airlines · KL 757 Depart at 12:55pm from Amsterdam (AMS) Fly for 10h 55m Arrive at 4:50pm in Panama (PTY)

Tue Jun 24th 2025 KLM Royal Dutch Airlines · KL 8885 Depart at 6:33pm from Panama (PTY) Fly for 1h 24m Arrive at 7:57pm in Medellín (MDE)

Sat Jul 12th 2025 KLM Royal Dutch Airlines · KL 1816 Depart at 10:15am from Frankfurt (FRA) Fly for 1h 10m Arrive at 11:25am in Amsterdam (AMS)

Sat Jul 12th 2025 KLM Royal Dutch Airlines · KL 757 Depart at 12:55pm from Amsterdam (AMS) Fly for 10h 55m Arrive at 4:50pm in Panama (PTY)

Sat Jul 12th 2025 KLM Royal Dutch Airlines · KL 8885 Depart at 6:33pm from Panama (PTY) Fly for 1h 24m Arrive at 7:57pm in Medellín (MDE)

Wed Jul 2nd 2025 KLM Royal Dutch Airlines · KL 1816 Depart at 10:15am from Frankfurt (FRA) Fly for 1h 10m Arrive at 11:25am in Amsterdam (AMS)

Wed Jul 2nd 2025 KLM Royal Dutch Airlines · KL 757 Depart at 12:55pm from Amsterdam (AMS) Fly for 10h 55m Arrive at 4:50pm in Panama (PTY)

Wed Jul 2nd 2025 KLM Royal Dutch Airlines · KL 8885 Depart at 6:33pm from Panama (PTY) Fly for 1h 24m Arrive at 7:57pm in Medellín (MDE)

Fri Jul 4th 2025 KLM Royal Dutch Airlines · KL 1814 Depart at 7:00am from Frankfurt (FRA) Fly for 1h 5m Arrive at 8:05am in Amsterdam (AMS)

Fri Jul 4th 2025 KLM Royal Dutch Airlines · KL 757 Depart at 12:55pm from Amsterdam (AMS) Fly for 10h 55m Arrive at 4:50pm in Panama (PTY)

Fri Jul 4th 2025 KLM Royal Dutch Airlines · KL 8885 Depart at 6:33pm from Panama (PTY) Fly for 1h 24m Arrive at 7:57pm in Medellín (MDE)

Tue Jul 29th 2025 KLM Royal Dutch Airlines · KL 1816 Depart at 10:15am from Frankfurt (FRA) Fly for 1h 10m Arrive at 11:25am in Amsterdam (AMS)

Tue Jul 29th 2025 KLM Royal Dutch Airlines · KL 757 Depart at 12:55pm from Amsterdam (AMS) Fly for 10h 55m Arrive at 4:50pm in Panama (PTY)

Tue Jul 29th 2025 KLM Royal Dutch Airlines · KL 8885 Depart at 6:33pm from Panama (PTY) Fly for 1h 24m Arrive at 7:57pm in Medellín (MDE)

Sun Jul 13th 2025 KLM Royal Dutch Airlines · KL 1816 Depart at 10:15am from Frankfurt (FRA) Fly for 1h 10m Arrive at 11:25am in Amsterdam (AMS)

Sun Jul 13th 2025 KLM Royal Dutch Airlines · KL 757 Depart at 12:55pm from Amsterdam (AMS) Fly for 10h 55m Arrive at 4:50pm in Panama (PTY)

Sun Jul 13th 2025 KLM Royal Dutch Airlines · KL 8885 Depart at 6:33pm from Panama (PTY) Fly for 1h 24m Arrive at 7:57pm in Medellín (MDE)

Sun Jun 29th 2025 KLM Royal Dutch Airlines · KL 1816 Depart at 10:15am from Frankfurt (FRA) Fly for 1h 10m Arrive at 11:25am in Amsterdam (AMS)

Sun Jun 29th 2025 KLM Royal Dutch Airlines · KL 757 Depart at 12:55pm from Amsterdam (AMS) Fly for 10h 55m Arrive at 4:50pm in Panama (PTY)

Sun Jun 29th 2025 KLM Royal Dutch Airlines · KL 8885 Depart at 6:33pm from Panama (PTY) Fly for 1h 24m Arrive at 7:57pm in Medellín (MDE)

Mon Jul 14th 2025 KLM Royal Dutch Airlines · KL 1816 Depart at 10:15am from Frankfurt (FRA) Fly for 1h 10m Arrive at 11:25am in Amsterdam (AMS)

Mon Jul 14th 2025 KLM Royal Dutch Airlines · KL 757 Depart at 12:55pm from Amsterdam (AMS) Fly for 10h 55m Arrive at 4:50pm in Panama (PTY)

Mon Jul 14th 2025 KLM Royal Dutch Airlines · KL 8885 Depart at 6:33pm from Panama (PTY) Fly for 1h 24m Arrive at 7:57pm in Medellín (MDE)

Tue Jul 22nd 2025 KLM Royal Dutch Airlines · KL 1816 Depart at 10:15am from Frankfurt (FRA) Fly for 1h 10m Arrive at 11:25am in Amsterdam (AMS)

Tue Jul 22nd 2025 KLM Royal Dutch Airlines · KL 757 Depart at 12:55pm from Amsterdam (AMS) Fly for 10h 55m Arrive at 4:50pm in Panama (PTY)

Tue Jul 22nd 2025 KLM Royal Dutch Airlines · KL 8885 Depart at 6:33pm from Panama (PTY) Fly for 1h 24m Arrive at 7:57pm in Medellín (MDE)